Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid
نویسندگان
چکیده
منابع مشابه
Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid.
Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and...
متن کاملPhase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease.
Valaciclovir, the L-valyl ester of acyclovir, is rapidly and extensively converted in humans to acyclovir after oral administration by first-pass metabolism. A phase I study was conducted in two cohorts of volunteers with advanced human immunodeficiency virus (HIV) disease (absolute CD4 lymphocyte count of < 150 cells per microliters) who received oral valaciclovir at dosages of 1,000 or 2,000 ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1996
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/37.2.383